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Therefore, approaches that quantify the anti-tumor immune response in solid tumors may not be directly applicable in MDS ( 3.3 Absolute monocyte counts and subsets in MDS The diagnostic criteria for MDS dictate that the absolute number of PB monocytes should not exceed 0.5x10^9/L, as surpassing this threshold would classify it as chronic myelomonocytic leukemia (CMML) ( A lower absolute monocyte count in PB and a higher lymphocyte-to-monocyte ratio (LMR) in PB are both linked to poor survival outcomes ( The general distribution of monocyte subsets in PB and BM is similar in MDS and healthy conditions ( Figure 3 )

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Ang WH, Khalaila I, Allardyce CS, Juillerat-Jeanneret L, Dyson PJ

Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation