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Wade L, Neudorff L, et al

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From the perspective of clinical translation, existing evidence provides preliminary support for the feasibility of this shiftcurrent human trials typically employ administration periods exceeding 4 weeks (Table 3), establishing a foundation for evaluating long-term efficacy and safety

Dosing & Reconstitution Guide Educational guide for reconstitution and nightly dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Inject once daily subcutaneously in the evening, approximately 3060 minutes before bedtime [4]