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However, a recently published phase II clinical trial using the iron chelator deferiprone reported that deferiprone was ineffective in newly diagnosed PD patients who had not previously received dopaminergic therapy and even worsened both motor and non-motor symptoms [177]

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SSG control Under homeostatic conditions, CASP8 acts as the primary molecular "brake" on necroptosis by cleaving and inactivating RIPK1 and RIPK3