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Succinic dehydrogenase subunit A deficiency (OMIM #252011) Succinic dehydrogenase subunit A (SDHA), a flavoprotein with FAD as cofactor, is a nuclear encoded and catalytic subunit of Complex II (succinate dehydrogenase) which oxidizes succinate to fumarate in the Krebs cycle and transfers electrons to ubiquinone in the mitochondrial electron transport chain [115]

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CRISPR can also be used to modify genes at their endogenous loci with fluorescently-tagged versions for imaging purposes