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Nonetheless, glioma represents a malignancy with high heterogeneity which the glioma lipidome also possesses, with specific fatty acids and saturation states in distinct subclasses

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The patients were randomly allocated to the conventional hydroquinone 4% and liposomal hydroquinone 4% groups and the melasma severity was assessed through the MASI score at defined time points

Among the various lipids, phospholipid-related polyunsaturated fatty acids (PUFAs) such as phosphatidylethanolamine (PE) and phosphatidylcholine (PC) play key role in ferroptosis as the substrates for lipid peroxidation