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The body appears to have evolved specific mechanisms for this regulationone of which involves Siglec-8 and sialic acids as a negative feedback pathway to turn off eosinophils when they start causing tissue injury

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In IBD management, achieving mucosal healing has emerged as a paramount therapeutic goal, strongly associated with sustained remission and improved long-term outcomes ( 3.1 Peripheral blood eosinophilia in IBD The correlation between eosinophilia in peripheral blood and disease has been recognized since very early times, for example, Machella and Hollan reported that steroid-refractory ulcerative colitis shows eosinophilia at the initial diagnosis ( 9 /L) is more prevalent in IBD than in healthy controls

2024;78(6):360-366 Plans-Beriso E

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