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Erastin, a ferroptosis inducer, inhibits the activity of the cystine/glutamate antiporter, blocking the synthesis of glutathione and weakening the cells antioxidant capacity, ultimately leading to ferroptosis

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Additionally, iron chelating agents, including chloroiodohydroxyquine and its derivatives, as well as antioxidants, have shown efficacy in animal models of AD, though clinical trials are yet to be conducted (27,106,116)

In the hypoglycemic and hypoxic TME, Teffs suffer from repressed mitochondrial biogenesis, specifically via the loss of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) [10, 163]

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