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Br J Pharmacol 133:936944 Lombardi G, Miglio G, Canonico PL, Naldi P, Comi C, Monaco F (2003) Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients

Additionally, oxidative stress reduces nitric oxide (NO) bioavailability, inducing accumulation of asymmetric dimethylarginine (ADMA) and prompting an increased arginase activity (9), thus impairing vasodilation (22)