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Due to the limitations of the OECD TG 117 HPLC derived log K OW data, the ECHA Guidance [15] calls to support these with QSAR generated estimates, especially if the log K OW is in the range of 1 log unit below or above the screening value of log K OW = 4.5

6d, SI section 9.1)

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[8] According to mathemetical modeling, the futile cycle could act as a dampener in the broader network of folate-mediated one-carbon metabolism, stabalizing it against stochastic noise from folate deficiency and/or reduced MTHFR activity due to genetic variation