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Although the study achieved an ORR of 18%, it was terminated early because of dose-dependent, on-target/off-tumor toxicity affecting skin, eyes, and ears, including one treatment-related death at the highest dose level, illustrating the narrow therapeutic window of differentiation antigens shared with normal melanocytes [187]

Finally, the hydroxyl radical attacked the hydroxyl groups of leucodopachrome to form dopachrome

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If this level was used as in the experiments above, the mice would have been injected with 0.2 ml of liquid containing 0.68 nanograms of GHK

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