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Amoeboid cells exhibit weak adhesions, show high dependence on actomyosin contractility, and utilize spherical bulges known as membrane blebs for efficient migration, invasion, and extravasation [166,167,168]

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In our study, we used higher concentration of TA (500 mg/5 ml) and observed that on right cheek, there was significant reduction in VAS score from baseline to 8th week and baseline to 12th week, suggesting that TA was more effective in treatment of facial melasma

Recent work further revealed that peroxiredoxin 6 (PRDX6) binds GPX4 via a C47-mediated disulfide interaction to facilitate GPX4 membrane association and ferroptosis protection 100