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demonstrated that the expression of outer membrane proteins from family 5 efflux pumps, including hefa ( HP0605 ), hefd ( HP0971 ), and hefG ( HP1327 ), was significantly greater in biofilm-forming cells than in planktonic cells (Yonezawa et al., 2019)

The standard starting protocol consists of 2 mg administered subcutaneously twice weekly

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This heterogeneity complicates the elucidation of pharmacokinetic and pharmacodynamic profiles, particularly in compounded preparations, thereby hindering standardization and clinical validation