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AR inhibition prevented growth factor-induced proliferation of colon cancer cells by arresting cells in the G1 phase, blocking phosphorylation of retinoblastoma protein and cyclin-dependent kinase (cdk)-2, and downregulating the expression of proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin E, cdk4, and c-myc [120,121]

The dry and wet forms of beriberi involve peripheral neuropathy, whereas cerebral beriberi can lead to neuronal cell death and the clinical conditions of Wernicke's encephalopathy and Korsakoff's psychosis, especially in those who chronically abuse alcohol (22, 24)

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FIGURE 1 Improvement of learning and memory function in PD by Rg1 In the treatment of PD patients, Rg1 produces substantial improvements in cognitive functions (including learning and memory) through the activation of multiple biological pathways

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