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In many occasions, for ADCs containing disulfide linkers, lysosomal processing is necessary for drug activation

GSH is an important component of the cellular antioxidant system and plays an important role in the treatment of tumours, and GSH can also trigger ferroptosis by interfering with cystine/glutamate reverse transporter proteins (systems Xc - ), inactivating GPX4, or depletion of GSH [7]

An integrated physical optimization framework for proton stereotactic body radiation therapy flash treatment planning allows dose, dose rate, and linear energy transfer optimization using patient-specific ridge filters

Moreover, in Alzheimer's brains, high levels of acrolein were detected in hippocampus and temporal cortex, where oxidative stress is high (Dang et al., 2010)

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