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(6) By using NPs as a carrier, compared with free loading of agents, antibacterial properties at a low dose against biofilm-derived planktonic cells and biofilms can be enhanced by improving the therapeutic index and the pharmacokinetic profile of the encapsulated antimicrobial drugs

A former professional runner who was never associated with the Oregon Project, but used to compete against Salazar says that a few other athletes would privately call him Albuterol Salazar, after the name of a popular asthma drug, because he always seemed to have some prescription

When stratified by comparator groups, the pooled estimate was most favorable in monotherapy trials versus placebo (SMD 2.41, 95% CI 4.43 to 0.39), whereas the add-on designs versus the same background treatment (SMD 0.65, 95% CI 1.85 to 0.55), head-to-head comparisons versus another drug (SMD 0.19, 95% CI 0.84 to 0.45), and add-on designs versus placebo (SMD 0.65, 95% CI 1.35 to 0.06) showed more modest estimates and did not provide clear evidence of a between-group difference overall (p=0.21)

10.1007/s00402-021-04030-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 9.Gorasso V, Van der Heyden J, De Pauw R, Pelgrims I, De Clercq EM, De Ridder K, et al

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