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Another recent screening identified that H3K9 demethylation-mediated upregulation of BCAT1 and subsequent BCAA metabolic reprogramming is able to enhance the capacity for sublethal epidermal growth factor receptor (EGFR) inhibitor (TKI) resistance by producing ROS scavengers in lung cancer, which is a cancer where EGFR mutations are commonly found (Wang et al., 2019b)

Abiotic stress adversely affects the growth, development, crop yield, and productivity of plants

Recently, the Pacold group identified 4-HPPA dioxygenase-like protein (HPDL) as the enzyme responsible for this transformation, using ^18O 2 gas labeling and metabolomics techniques 29

Methenni et al

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