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Simultaneously, the catabolite of indolepropionic acid acted as a ligand of the pregnane X receptor and showed the effect of adjusting the intestinal barrier function at the existence of indoles (Venkatesh et al., 2014)

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Based on these preclinical data, an early clinical study showed that solid grafts of adrenal medullary tissue, known to produce catecholamines, including dopamine, placed into the caudate nucleus through an open microsurgical procedure, had significant benefits in two patients with PD (Madrazo et al

A multicellular tumor spheroid is a tissue culture model that mimics the pathological conditions of solid tumors including a three-dimensional cellular structure, nutrition, and proliferation gradients