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Although our data indicate that myeloid-specific deficiency of Infgr1 resulted in improved insulin sensitivity by protecting adipose-resident macrophages from apoptosis, we cannot rule out the contributions of reduced food intake, increased activity, and reduced fat mass to the beneficial effects Future studies will be required to examine the significance of SerpinB2 expression by the macrophage subsets in infection clearance

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2003 Oxidative damage of the macromolecules increases with age and has been suggested to contribute importantly to the aging process and the pathogenesis of many age-related diseases