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Mutations in the HFE gene are the major cause of hereditary hemochromatosis, a genetic disorder characterized by impaired regulation of TfR-mediated iron uptake, leading to excessive iron absorption and iron overload in organs such as the liver, heart, pancreas, and joints, ultimately resulting in tissue damage (Brissot et al., 2018

This finding brought together the antioxidant property of UA with the consistently topical concept of oxidative stress as a critical factor in the pathogenesis of PD

Acknowledgements We thank Yale School Medicine, Yale West Campus, Systems Biology Institute and Cancer Biology Institute for the instrumentation supports

[DOI] [PubMed] [Google Scholar] 12.Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangli A, Cantin A, Saltini C, Cantin AM, Crystal RG

This condition manifests as flat brownish or blue-grey patches, primarily on the face, predominantly affecting women