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Malcolm, teamed up with an American think tank called the Reason Foundation which was interested in carrying out a case study that delved into the federal excise tobacco cuts by the Jean Chretien Liberal government in the 1990s

Liver enzymes, specifically those in the cytochrome P450 family, break down HHC into several metabolites, including 11-hydroxy-hexahydrocannabinol (11-OH-HHC) and 11-nor-9-carboxy-hexahydrocannabinol (HHC-COOH).** These metabolites mirror the metabolic pathway of Delta-9 THC, with 11-OH-HHC being the primary active metabolite responsible for THC-like effects

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It complements both mainstream and more modern interpretations by reinforcing the importance of traditional tobacco profiles