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Chl content and ALA-synthesizing capacity consistently remained wild-type-like ( Supplementary Figures 3B, C ) with the striking exception of GSAAT(C190S), which exhibited a significantly lower rate of ALA synthesis

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The common subtypes of migraine are primarily polygenic, involving complex interactions among multiple genetic variants, each contributing modestly to disease susceptibility (van den Maagdenberg et al., 2019)

Upon delivery to CNS, they degrade primarily via acid hydrolysis into their monomers (lactic and glycolic acids)

KRAS G12C inhibitors represent a significant breakthrough in the treatment of cancers driven by KRAS mutations