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In animal studies, trichloroethylene appears to be a weak genotoxicant

As part of the PDH complex, PDHB participates in the decarboxylation of pyruvate and is involved in the glycolytic pathway, thereby modulating cellular energy metabolism

Biomed Pharmacother 156:113848 Wen J, Li A, Wang Z, Guo X, Zhang G, Litzow MR, Liu Q (2025) Hepatotoxicity induced by arsenic trioxide: clinical features, mechanisms, preventive and potential therapeutic strategies

In the steady state there is no anemia, no evidence of increased red cell destruction, nor alteration in blood morphology

Normally the H 2 O 2 is then inactivated by glutathione peroxidase but it can be converted, chemically, by Fe 2+ ions (Fenton reaction) into the highly reactive hydroxyl radical