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Astrocytes play a key role in the development, maintenance, and function of the blood-brain barrier (BBB), and BBB dysfunction has been observed in SCZ patients (Stanca et al., 2024

In addition, Baschnagel et al

subtilis , as a spore-forming Gram-positive probiotic, exhibits greater acid and heat tolerance as well as whole-gut colonization capacity, contributing to intestinal homeostasis and protecting against liver injury

The main goals of pre-maintenance are to: Accustom yourself to a lifetime eating plan Determine your CCLMthe best carbohydrate level in which you can feel the happiest and healthiest without experiencing cravings and regaining weight Understand that your CCLL can shift and why Increase awareness of situations that can shift you away from your goals (i.e.: social gatherings, parties, special occasions, holidays) Offer an even wider variety of food choices than the other two phases Internalize your responses to distracting situations from your weight loss goals Develop flexible lifestyle eating habits and choices to help sustain your weight loss It is recommended to stay in this phase until you lose the final 4-5 pounds and reach your weight loss goal

1a,b and Supplementary Figs