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A RCT showed that daily supplementation with 220 mg zinc sulfate (equivalent to 50 mg elemental zinc) for 8 weeks led to marked improvements in multiple metabolic parameters relative to placebo

These data suggest that GSH synthesis, potentially through NRF2 repression, also limits NRF1 protein expression in the liver

Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

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Adipose tissue metabolism and inflammation are differently affected by weight loss in obese mice due to either a high-fat diet restriction or change to a low-fat diet