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Side Effects and Risks For a healthy adult getting a routine drip from properly trained staff, IV therapy is usually well tolerated

Apply on clean, dry skin

The CaP-lipid NPs can effectively deliver SOD1-targeting ASOs into the NSC-34 cell line and suppress SOD1 expression in HEK293 cells [166]

Nevertheless, multiple clinical trials testing different cyclic dinucleotides [e.g., BMS-986301 (NCT03956680) or BI 1387446 (NCT04147234)] either alone or in combination with other cancer therapies are currently ongoing and will ultimately determine the future relevance of STING agonists in a clinical setting (www.clinicaltrials.gov)

Abbreviations AOR: Adjusted odds ratio CI: Confidence interval FM: Fibromyalgia FSDC: Fibromyalgia Survey Diagnostic Criteria GAD-7: Generalized Anxiety Disorder 7-item scale SSS: Symptom Severity Scale WPI: Widespread Pain Index References Clauw DJ