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For ATF2, multiple upstream intervention strategies have been explored, including p38 MAPK inhibitors (SB203580) and JNK inhibitors (SP600125), which reduce inflammation by suppressing ATF2 phosphorylation (166)

Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia

Additionally, appropriate human longitudinal studies and standardized protocols for measuring durability and safety of microbiota-based interventions among different patient populations will be important