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To confirm that iMQT_020 acts as a noncompetitive allosteric inhibitor of SLC1A5_var, we generated LineweaverBurk plots of iMQT_020, V-9302, and L--glutamyl-p-nitroanilide (GPNA) at 10 M (Fig

:) Love, Helen

28 GhateN.ChaudhuriD.DasA.PanjaS.MandalN

TB-500 operates systemically as a **cytoskeleton remodeler**: its primary function is G-actin monomer sequestration (active N-terminal Ac-Ser-Asp-Lys-Pro), its cleaved AcSDKP sequence is an **autonomous angiogenic factor**, it upregulates laminin-5 and matrix metalloproteinases (MMPs), and mobilizes mesenchymal progenitor cells