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The preference for certain synonymous codons, even within the same gene, can significantly impact both protein levels and structure (Gustafsson et al., 2012

For those under severe chronic stress, or who are engaged in strenuous work/athletic training that promotes intense sweating even higher levels might be required, up to 10 milligrams per kilogram of body weight, or 4.5 milligrams per pound." For a 165-pound athlete, that translates into a daily total of approximately 446 mg to 743 mg of magnesium