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Direct injection onto lyophilized powder causes mechanical shear and foaming, which risks peptide degradation

Deficiency of Vitamin B12 greatly reduces the ability to make adrenalin from the precursors dopamine and nor-adrenalin Deficiency of Vitamin B12 greatly reduces the ability to make melatonin from the precursor serotonin Prolonged deficiency of vitamin B12 eventually results in over-production of dopamine and serotonin Over-production of dopamine and serotonin leads to receptor down-regulation and DEPRESSION and/or ANXIETY Subsequent correction of vitamin B12 depression leads to a rapid drop in dopamine and serotonin and a sudden production of adrenalin and melatonin Symptoms of adrenalin over-production are common Greater depression and/or anxiety can ensue Production of Adrenalin/epinephrine is critically dependent upon active methyl-Co(III)B12

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Vitamin B(12) deficiency after gastrectomy for gastric cancer: an analysis of clinical patterns and risk factors

de Jong JMA, Sun W, Pires ND, Frontini A, Balaz M, Jespersen NZ, et al