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617 Exposure of astrocytes to -amyloid down-regulates expression of glutamine synthetase, 618 and in animal models, glutamine synthetase expression is reduced in astrocytes surrounding -amyloid plaques

A subsequent investigation corroborated similar findings

At the time of writing, APAP is probably the most widely available and commonly used drug worldwide and represents a very important analgesic;1 indeed it is included in the 20 th World Health Organization Model List of Essential Medicines as updated in March 2017.2 Some 60 years after its introduction as a therapeutic agent in the UK, APAP remains a compound of great interest, not only because of its therapeutic properties but also for its ability to cause hepatotoxicity in overdose