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The physiological mechanism is plausible, the published research supports the indication, and the side-effect profile is favorable

This specific enzymatic activity appeared as the top functionally decreased activity in the intestinal microbiome of FM patients (Figure 3b) and is involved in the main pathways altered in FM patients, as indicated by our data

Experimental data on animal models have suggested that GIP suppresses peripheral arterial remodeling, thus showing an anti-atherosclerotic activity, by acting on receptors in the heart and vessels." Outcomes of clinical trials The first clinical trial to test the clinical efficacy of TZP was the SURPASS program, a six-stage trial conducted on three separate cohorts Japanese (SURPASS-J), Asian-Pacific (SURPASS-AP), and the cardiovascular outcome trial (SURPASS-CVOT)

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The reaction likely proceeds by the opening of the hemiacetal ring, followed by the reduction of the aldehyde group to alcohol (Figure 4C)