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For cell-based systemic regeneration, it is the better-characterized tool [7](#ref-7)[8](#ref-8)

This interaction with the pineal gland not only improves sleep quality but also has broader implications for hormonal balance and overall well-being

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DMSO is known to cause malformation in rodent embryos 17 , and we found that most of the zebrafish embryos treated with 5% (v/v) DMSO from 1.5 h post-fertilisation (hpf) died before 24 hpf, while 4 out of 27 embryos survived with severe malformation (Fig