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Naltrexone-bupropion (Contrave) primarily causes nausea rather than diarrhea, affecting approximately 30% of users initially

doi: 10.1002/gepi.21965 36

Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice

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However, if the B12 deficiency causes is more acute or if absorption issues exist, such as pernicious anemia or after surgery to the gastrointestinal tract, vitamin B12 may need to be given intramuscularly