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Chronic CIPN was defined in only 4 trials [20] [22] [25] [27], as the beginning of the symptoms at least 1 or more months

The activation of AMP-activated protein kinase can result in BM loss and increase energy metabolism by decreasing gluconeogenesis and fatty acid production and boosting catabolism (Reference Long and Zierath124)

Paudel, S., Wu, G., & Wang, X

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Based on its psychoactive effects, kratom is increasingly used as a natural and presumably safe alternative for managing pain and opioid withdrawal symptoms