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Phosphorylated Smad2/3 then form a complex with Smad4, which translocates to the nucleus to activate TGF- target genes, including -SMA, collagen, fibronectin, and MMPs [8] (Fig

Rossi RE, Monasterolo G, Incorvaia C, Moingeon P, Frati F, Passalacqua G et al (2010) Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy