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In particular, increased oxidative stress has been observed in the brains of children with ASD (76)

However, in other rodents or mammals, selenocysteine cannot be synthesized due to the lack of selenocysteine insertion sequences in related genes, and it is a non-selenium protein replaced by cysteine (Cys) (Brigelius-Floh and Maiorino, 2013)

X MedChemExpress (MCE) has not independently confirmed the accuracy of these methods

It is well documented that pharmacological inhibition of GCL activity 4 or knockdown of the catalytic GCL subunit 5 increases ROS abundance, which mediates cellular damage