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Studies show less than 10% reaches systemic circulation due to degradation by peptidases in the small intestine

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The effectiveness of this method was evaluated with four model compounds including acetaminophen, clozapine, diclofenac, and nefazodone in both liver microsome and cryopreserved hepatocyte incubations

Front Pharmacol 15:1367848 Pinto YM, Elliott PM, Arbustini E, Adler Y, Anastasakis A, Bhm M, Duboc D, Gimeno J, de Groote P, Imazio M, Heymans S, Klingel K, Komajda M, Limongelli G, Linhart A, Mogensen J, Moon J, Pieper PG, Seferovic PM, Schueler S, Zamorano JL, Caforio AL, Charron P (2016) Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases

While vitamin A has seemingly only moderate effects on the immune system in healthy study participants, it reduces disease progression and vitamin A deficiency results in increased susceptibility to bacterial and viral infections as well as inflammatory processes