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Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease

Intestinal microorganisms metabolize TML into trimethyl-5-aminovaleric acid (TMAVA), which can competitively inhibit the binding of -BB to BBD, thereby inhibiting carnitine biosynthesis and FAO in the liver, promoting steatosis and aggravating fatty liver [250]

Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia Email: [email protected] ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 2 American MD Program, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Explor Cardiol

Other studies have demonstrated a dose-dependent effect of acetyl-l-carnitine in counteracting oxidative stress caused by arsenic and improved mitochondrial function in a rat hippocampus model and reduced the levels of free radicals induced by cuprizone in murine corpus callosum [21, 22]