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Colibactin acts as a crosslinking agent, forming covalent interstrand crosslinks between adenine residues in double-stranded DNA

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The bone marrow shows erythroid and myeloid precursors with distinctive vacuolation and ultrastructurally abnormal mitochondria

7.2 Translational gaps in antioxidant-based interventions Clinical evidence supporting pharmacological antioxidants such as melatonin, coenzyme Q10, N-acetylcysteine, and dietary polyphenols remains limited and heterogeneous