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Even so, some people with celiac disease might need B12 supplements

Choosing between the two depends on whether your priority is deeper support for the body or quicker symptom relief

For individuals with impaired absorption, genetic variations such as MTHFR mutation, or increased metabolic demand, methyl-B12 injections provide a direct and highly effective method to restore and maintain optimal levels

That makes it the most cost-effective vial size for most researchers

Pernicious anemia is a B12 deficiency anemia caused by the lack of intrinsic factor.[ref] What causes the lack of intrinsic factor in pernicious anemia