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Patients with a diagnosis of cirrhosis or decompensated liver disease were excluded at the time of entry to the study

Characterized by iron toxicity accumulation, phospholipid peroxidation and dysfunctional mitochondria, ferroptosis is intricately linked to the hepatic microenvironment, influencing and being influenced by factors such as iron homeostasis, glucose metabolism, lipid metabolism, amino acid metabolism, and the gut-liver axis

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Thus, identification of the molecular targets of -HB will provide a better understanding of how calorie restriction or a ketogenic diet improves age-related disease symptoms