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doi: 10.1126/science.adf8972 356 Santos-JniorC

Activation of the IKK is stimulated upon ligand binding by cytokine receptors, such as the TNFR and interleukin-1 receptor (IL-1R), as well as pattern recognition receptors (PRRs), including TLR4, and antigen receptors [38]

In this case, by promoting inflammation (through pro-inflammatory cytokines) and inducing apoptosis at an early stage, these concentrations effectively reduced replication of the PRRSV virus to bring about the observed effects (107)

MicroRNAs Mediate Oleic Acid-Induced Acute Lung Injury in Rats Using an Alternative Injury Mechanism

However, one study (Payabvash et al., 2006) showed that a major part of hepatic GSH depletion during endotoxemia is a fall in GCL activity, which as associated with a fall in GCLC mRNA level