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62,99,100 Together, these reports provide strong evidence that after an APAP overdose, in vivo and in isolated hepatocytes in culture, ferrous iron can be released from lysosomes and then taken up into mitochondria via the MCFU, where it contributes to MPTP opening and cell death (Fig

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Competing interest COPE No competing interests were disclosed

4 US Patents [2] of research Reviewed Studies [3] The PRUVN Study on Glutathione: Double-blinded, placebo-controlled study, approved by the University of Santa Catarina (UNISUL) Ethics Committee (Protocol #6.597.558) (2023)