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B12 deficiency may show itself as feeling fatigued, constipated, depressed or even dizzy

FIGURE 2 Causes of B12 deficiency and criteria for diagnosis The absorption and metabolic pathway for B12 is highly complex, and defects in any part of this process can lead to therapeutic B12 replacement

Treatment of deficiency Supplementation with B 12 is conducted to treat deficiency either orally (if vegan diet) or parenterally (if atrophy gastritis)

By easing the liver's workload, it can devote more energy to processing fat supporting both weight loss and overall health

223 In a randomized controlled trial in 30 women with fibromyalgia and vitamin D levels below 32 ng/mL, 1,200 IU (30 mcg) or 2,400 IU (60 mcg) of vitamin D3 daily, depending on baseline levels, for 20 weeks led to marked reduction in symptom severity and improved physical function compared with placebo