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Qualitative and quantitative validations of in silico model predictions In order to validate the qualitative model predictions, we simulated fermentable substrate phenotyping for various carbon sources and compared the results with experimental literature 46,47

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Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

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NNMT inhibition or NNMT knockdown improves insulin sensitivity and normalizes glucose tolerance and fasting blood glucose levels [14], but the mechanisms by which NNMT regulates insulin sensitivity and blood glucose homeostasis are unclear