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However, among the existing clinical studies, only a limited number of interventions have reported the participation rates of enrolled patients (70%-95%) [181, 182, 185]

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Mitochondrion-targeting drugs can induce tumor mtDNA oxidation and release to the cytoplasm, activate the cGAS-STING pathway, while mitochondrion Lipid peroxidation and ROS can also promote mtDNA release

9 , 803818.e11 (2021)

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