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A temporal dynamics study revealed that these gene expression changes followed a biphasic pattern, with early pro-inflammatory gene activation followed by later anti-inflammatory gene upregulation, consistent with an immunomodulatory rather than immunosuppressive profile

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Conclusion: Combining open-source questionnaires into a RAMS score allowed stratification of patients with MASLD into differential lifestyle risk categories that correlated with baseline FIB-4 scores

Meanwhile the half-life of antipyrine increased linearly after age 30, likely due to age-related changes in liver drug distribution and elimination processes (Sotaniemi et al., 1997)