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Notably, researchers have documented that the peptide appears to upregulate NO production when it is deficient and downregulate it when excessive, suggesting a modulatory rather than simply stimulatory relationship

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans

Together, they decrease levels of TNF-, IL-6, and CRP, preventing chronic inflammation and promoting a stable biochemical environment for regeneration and repair

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