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Mild soreness at the site for a day or two afterwards is normal and feels similar to the morning after a tetanus or flu jab

There is ongoing debate about cardiovascular risks: some studies have suggested that testosterone treatment might be associated with a higher incidence of heart attack or stroke in older men, though definitive evidence is inconclusive

MOTS-c is the other common pairing in laboratory work on energy metabolism, since it acts on mitochondrial pathways and insulin sensitivity rather than on adrenergic receptors

other allergic reactions that have been reported include erythema, skin rash (unspecified), pruritus, general malaise, and respiratory difficulty due to bronchospasm

Common injection sites include the thigh, shoulder, and buttocks