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A multivariate random-effects model with a consistency assumption was used to estimate the adjusted relative effects (i.e

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A study from The University of Texas MD Anderson Cancer Center found that increasing doses of varenicline or switching from combined nicotine replacement therapy (CNRT) to varenicline significantly improved smoking cessation rates in patients who initially failed to quit

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That is, 0.05 mg/kg nicotine produced bupropion-appropriate responding similar to that produced by the original bupropion training dose (Wilkinson et al., 2009)